LAMP3基因表达与肾癌之间的因果关系：一项基于孟德尔随机化分析的研究

doi:10. 20223 / j. cnki. 1000-8535. 2026. 01. 013

广州医药 ›› 2026, Vol. 57 ›› Issue (1): 88-94.DOI: 10. 20223 / j. cnki. 1000-8535. 2026. 01. 013

LAMP3基因表达与肾癌之间的因果关系：一项基于孟德尔随机化分析的研究

吴金海^1,2, 王斌², 朱学进²

1 广州医科大学研究生院（广东广州 511495）;
2 广州医科大学附属肿瘤医院泌尿外科（广东广州 510095）

收稿日期:2025-02-19 发布日期:2026-02-03
通讯作者: 朱学进,E-mail：Xuejin_Alex@outlook.com
基金资助:
广东省自然粤穗联合青年基金项目（2022A1515111122）; 广州市科学技术局一般项目（2023A04J0598）; 广州市卫生健康科技项目（20231A011103）

Causal relationship between LAMP3 gene expression and renal cancer：A Mendelian randomization analysis

WU Jinhai^1,2, WANG Bin², ZHU Xuejin²

1 Graduate School,Guangzhou Medical University,Guangzhou 511495,China;
2 Department of Urology,Affiliated Cancer Hospital of Guangzhou Medical University,Guangzhou 510095,China

Received:2025-02-19 Published:2026-02-03

摘要/Abstract

摘要： 目的探讨溶酶体相关膜蛋白3（LAMP3）与肾癌发病风险之间的因果关系,为肾癌的分子致病机制提供新的理论依据。方法基于全基因组关联研究（GWAS）数据,采用孟德尔随机化分析方法,评估LAMP3基因表达与肾癌的因果关系。并通过GEPIA2分析LAMP3表达对肾癌总体生存期（OS）及无病生存期（DFS）的关系。结果 LAMP3基因变异与肾癌风险呈正相关,提示LAMP3的表达可能增加肾癌的发病风险。此外,GEPIA2分析进一步显示,LAMP3的高表达与肾癌患者的低总体生存期（OS）及无病生存期（DFS）显著相关。结论本研究通过孟德尔随机化分析探讨了LAMP3基因表达与肾癌的因果关系,结果表明LAMP3可能是肾癌的潜在致病因子,并与肾癌预后相关。这为肾癌的分子致病机制研究提供了重要的理论依据,并为未来的生物标志物和靶向治疗策略的开发提供了新的思路。

关键词: 孟德尔随机化, LAMP3, 肾癌

Abstract: Objective To investigate the causal relationship between LAMP3 expression and renal cancer risk using Mendelian randomization analysis,providing a theoretical basis for understanding the molecular mechanisms underlying renal cancer. Methods This study utilized data from genome-wide association studies（GWAS）and employed Mendelian randomization analysis to assess the causal relationship between LAMP3 gene expression and renal cancer.Additionally,GEPIA2 was used to examine the association between LAMP3 expression and overall survival（OS）and disease-free survival（DFS）in renal cancer patients. Results Variants in the LAMP3 gene were positively correlated with renal cancer risk,suggesting that LAMP3 expression may increase the likelihood of developing renal cancer.Furthermore,GEPIA2 analysis revealed that high expression of LAMP3 was significantly associated with lower OS and DFS in renal cancer patients. Conclusions This study explored the causal relationship between LAMP3 gene expression and renal cancer through Mendelian randomization analysis.The results indicate that LAMP3 may be a potential pathogenic factor in renal cancer and is associated with poor prognosis.These findings provide important theoretical insights into the molecular mechanisms of renal cancer and offer new perspectives for the development of biomarkers and targeted therapeutic strategies in the future.

Key words: Mendelian randomization, LAMP3, renal cancer

吴金海, 王斌, 朱学进. LAMP3基因表达与肾癌之间的因果关系：一项基于孟德尔随机化分析的研究[J]. 广州医药, 2026, 57(1): 88-94.

WU Jinhai, WANG Bin, ZHU Xuejin. Causal relationship between LAMP3 gene expression and renal cancer：A Mendelian randomization analysis[J]. Guangzhou Medical Journal, 2026, 57(1): 88-94.

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LAMP3基因表达与肾癌之间的因果关系：一项基于孟德尔随机化分析的研究

Causal relationship between LAMP3 gene expression and renal cancer：A Mendelian randomization analysis

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